Programmable one-pot synthesis of poly glucosamine.
Date Issued
2010
Date
2010
Author(s)
Chen, Chun-wei
Abstract
Nucleic acids and proteins are the polymers of linear structure in nature. They can be synthesized via chemically automatic synthesis. However, saccharides are usually branched and very complex in structure. Till now, there is no automatic machine available for saccharides synthesis. To tackle this problem, a new synthesis strategy based on the different RRV of thioglucosides in a programmable one-pot approach has been developed.
According to the previous studies, the RRV value is varied by changing amino protecting groups. There were eight different amino protecting groups of thioglycosides which had been synthesized in this thesis, and all of their RRV values were different in each other. Thereby, we confirmed that the RRV value is changed by different amino protecting group indeed.
By the one-pot synthesis, there are some trouble in glycosylation about Boc group. It is not suitable donor for glycosylation as the Boc group will be removed in acid condition. However, trisaccharide could be synthesized by compound 14, compound 18 and compound 21. Therefore,
V
we want to get more polymers as many as possible in the future and it will be a new strategy for the synthesis of poly N-Acetylglucosamine.
Subjects
one-pot
glucosamine
RRV
Type
thesis
File(s)![Thumbnail Image]()
Loading...
Name
ntu-99-R97223210-1.pdf
Size
23.32 KB
Format
Adobe PDF
Checksum
(MD5):bbec5a8db83f4eb42eeb1ecc4e6bd59b