Synthesis and antitumor activity of a series of osmium(IV) nitrido complexes bearing quinolinolato ligands
Journal
Chemical Communications
Journal Volume
49
Journal Issue
85
Pages
9980-9982
Date Issued
2013
Author(s)
Abstract
A series of osmium(IV) nitrido complexes supported by quinolinolato ligands have been prepared and they exhibit promising in vitro anti-cancer activities. These results establish that OsVI≡N is a potentially versatile and promising platform for the design of a variety of high-valent anti-cancer drugs. © 2013 The Royal Society of Chemistry.
SDGs
Other Subjects
Antineoplastic Agents; Apoptosis; Cell Proliferation; Cell Survival; Coordination Complexes; Ferric Compounds; Flow Cytometry; Hep G2 Cells; Humans; Inhibitory Concentration 50; Ligands; Molecular Structure; Osmium; antineoplastic agent; cisplatin; osmium derivative; osmium(vi)nitrido complex; quinoline derivative; quinolinolato ligand; unclassified drug; antineoplastic activity; article; cancer cell culture; controlled study; cytotoxicity; drug structure; drug synthesis; human; human cell; IC 50; in vitro study
Type
journal article