Pan-drug-resistant Pseudomonas aeruginosa causing nosocomial infection at a university hospital in Taiwan
Journal
Clinical Microbiology and Infection
Journal Volume
11
Journal Issue
8
Pages
670-673
Date Issued
2005
Author(s)
Abstract
This study evaluated the clinical and microbiological characteristics of 16 patients who were colonised or infected with 26 isolates of pandrug-resistant Pseudomonas aeruginosa (PDRPA; intermediately-resistant or resistant to all cephalosporins, piperacillin-tazobactam, aztreonam, carbapenems, ciprofloxacin and aminoglycosides) in a university hospital during 1999-2002. All the isolates had colistin MICs ?4 mg/L, 19 (73%) isolates had blaVIM-3, and 25 (96%) isolates had class I integrons (intI). Time-kill studies for two PDRPA blood isolates demonstrated synergism for cefepime-amikacin after 24 h. Pulsed-field gel electrophoresis analysis of the isolates revealed a polyclonal nature (12 pulsotypes), although clonal dissemination of PDRPA isolates among these patients was also present. ? 2005 Copyright by the European Society of Clinical Microbiology and Infectious Diseases.
SDGs
Other Subjects
amikacin; aminoglycoside antibiotic agent; aztreonam; carbapenem derivative; cefepime; ceftazidime; cephalosporin derivative; ciprofloxacin; colistin; imipenem; levofloxacin; meropenem; piperacillin plus tazobactam; adolescent; adult; aged; antibiotic resistance; article; bacterial colonization; bactericidal activity; bacterium isolate; catheter infection; clinical article; clinical feature; drug potentiation; female; Gram negative infection; hospital infection; human; integron; male; minimum inhibitory concentration; nonhuman; priority journal; Pseudomonas aeruginosa; pulsed field gel electrophoresis; school child; Taiwan; university hospital; urinary tract infection; ventilator associated pneumonia; Pseudomonas aeruginosa
Type
journal article