Acute leukemic transformation of myelodysplastic syndrome-Immunophenotypic, genotypic, and cytogenetic studies
Journal
Leukemia Research
Journal Volume
19
Journal Issue
9
Pages
595-603
Date Issued
1995
Author(s)
Wang C.-H.
Chuang S.-M.
Lee F.-Y.
Liu M.-C.
Lin K.-H.
Lin D.-T.
Abstract
The clinical and biological characteristics of myelodysplastic syndrome (MDS) in acute leukemic transformation were studied in 23 patients. All had myeloid transformation according to FAB criteria, but coexpression of lymphoid-associated antigens was detected in five of the 20 patients who underwent an immunophenotypic study. Rearrangement of the immunoglobulin heavy chain gene was also observed in one of the five patients who coexpressed lymphoid markers and that of the T-cell receptor β chain gene in another one. None had pure lymphoid transformation. Clonal chromosomal abnormalities were noted in 12 (63%) of the 19 patients who underwent cytogenetic study, most commonly -7 (six patients or 32%). In the 18 patients who underwent serial analyses both at MDS diagnosis and at acute transformation, seven (39%) underwent karyotypic evolution. The most common new or additional aberrations were +8 and +21. N-ras gene mutation was detected in two of the nine patients at acute leukemic transformation. The median interval from diagnosis of MDS to onset of acute transformation was 10 months (1-36 months). Patients with a normal karyotype at diagnosis had a significantly longer chronic phase duration than those with chromosomal abnormalities (median of 20 months vs. 5 months). However, all had a short survival time after diagnosis of acute leukemia, whether chromosomal anomalies were present or not. ? 1995.
SDGs
Other Subjects
immunoglobulin heavy chain; t lymphocyte receptor beta chain; acute leukemia; adolescent; adult; aged; article; child; chromosome 21; chromosome 8; chromosome aberration; clinical article; cytogenetics; disease course; female; gene mutation; gene rearrangement; genotype; human; immunoglobulin gene; immunophenotyping; karyotype evolution; male; myelodysplastic syndrome; oncogene ras; priority journal; survival time; t lymphocyte receptor gene; Adolescent; Adult; Aged; Cell Transformation, Neoplastic; Child; Chromosome Aberrations; Chromosome Disorders; Female; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; Genes, Immunoglobulin; Genes, ras; Human; Immunophenotyping; Leukemia; Male; Middle Age; Myelodysplastic Syndromes; Point Mutation; Support, Non-U.S. Gov't
Type
journal article