Median nerve stimulation induces analgesia via orexininitiated endocannabinoid disinhibition in the periaqueductal gray
Journal
Proceedings of the National Academy of Sciences of the United States of America
Journal Volume
115
Journal Issue
45
Date Issued
2018
Author(s)
Abstract
mice. These findings suggest that PC6-targeting low-frequency MNS activates hypothalamic orexin neurons, releasing orexins to induce analgesia through a CB1R-dependent cascade mediated by OX1R-initiated 2-AG retrograde disinhibition in the vlPAG. The opioid-independent characteristic of MNS-PC6-induced analgesia may provide a strategy for pain management in opioid-tolerant patients.
SDGs
Publisher
National Academy of Sciences
Type
journal article