Modality switching between therapy and imaging based on the excitation wavelength dependence of dual-function agents in folic acid-conjugated graphene oxides
Journal
Biomedical Optics Express
Journal Volume
9
Journal Issue
2
Pages
705-717
Date Issued
2018
Author(s)
Abstract
Owing to its near infrared (NIR) absorption, graphene oxide (GO) is promising for both photothermal (PT) therapy and multiphoton (MP) imaging. Novel therapy/imaging modality switching is proposed here based on the selected excitation wavelength of femtosecond (FS) laser. GO-based destruction of cancer cells is demonstrated when the laser power of 800-nm-wavelength FS laser is increased above 7 mW. However, GO-based imaging is mainly monitored without damaging the sample when using 1200-nm wavelength FS laser in the same laser power range. Folic acid (FA) conjugated graphene oxide (FA-GO) was synthesized for selective cancer cell targeting. Dual-function FA-GO-based cancer cell targeting agents were experimentally optimized to enable therapy/imaging modality switching. ? 2018 Optical Society of America.
SDGs
Other Subjects
Cells; Diseases; Graphene; Infrared devices; Multiphoton processes; Organic acids; Cancer cell targeting; Cancer cells; Dual function; Excitation wavelength; Femtosecond (fs) laser; Graphene oxides; Near-infrared absorption; Photo-thermal; Laser excitation; folic acid; graphene oxide; Article; atomic force microscopy; controlled study; fluorescence imaging; human; human cell; infrared spectroscopy; multiphoton microscopy; photothermal therapy; three dimensional imaging; two-dimensional imaging; ultraviolet spectroscopy
Type
journal article