Effect of Induction Therapy With Olamkicept vs Placebo on Clinical Response in Patients With Active Ulcerative Colitis: A Randomized Clinical Trial
Journal
JAMA
Journal Volume
329
Journal Issue
9
Date Issued
2023-03-07
Author(s)
Zhang, Shenghong
Chen, Baili
Wang, Bangmao
Chen, Hong
Li, Yan
Cao, Qian
Zhong, Jie
Ran, Zhihua
Tang, Tongyu
Yang, Ming
Xu, Beibei
Wang, Qiang
Liu, Yunjie
Ma, Lijia
Wang, Xiaolin
Zhang, Nan
Zhang, Su
Guo, Wenyu
Huang, Liang
Schreiber, Stefan
Chen, Minhu
Abstract
Olamkicept, a soluble gp130-Fc-fusion-protein, selectively inhibits interleukin 6 (IL-6) trans-signaling by binding the soluble IL-6 receptor/IL-6 complex. It has anti-inflammatory activities in inflammatory murine models without immune suppression.
SDGs
Type
journal article