Association of apolipoprotein E polymorphism with lipoprotein glomerulopathy
Resource
Nephron v.78 n.3 pp.266-270
Journal
Nephron
Journal Volume
v.78
Journal Issue
n.3
Pages
266-270
Date Issued
1998
Date
1998
Author(s)
YANG, AN-HANG
KAO, JAU-TSUEN
Abstract
Two cases of lipoprotein glomerulopathy with a new apolipoprotein E (Apo E)genotype, epsilon3/epsilon4, were diagnosed recently. These 2 cases, together with other cases documented in English literature made a total of 6 common isoforms of Apo E encountered in lipoprotein glomerulopathy. Although the calculated allele frequency of epsilon2 is relatively high in cases with lipoprotein glomerulopathy as compared with that in the general population (39.3 vs. 6.4- 11.4%), the gradual emergence of Apo E isoforms other than E 2/E3 in lipoprotein glomerulopathy implicates that the genetic susceptibility of certain Apo E isoforms may not be a crucial factor. An alteration in the local environment of glomerular capillaries may be more important in the pathogenesis of lipoprotein glomerulopath.