Exposure to multiple low-level chemicals in relation to reproductive hormones in premenopausal women involved in liquid crystal display manufacture
Journal
International Journal of Environmental Research and Public Health
Journal Volume
10
Journal Issue
4
Pages
1406-1417
Date Issued
2013
Author(s)
Abstract
Background: Liquid crystal display (LCD) manufacturing involves three fabrication processes: array, panel and module processes, which result in different levels of volatile organic compound (VOC) exposure. The aim of this study was to assess the potential reproductive endocrine effects of occupational exposures during LCD manufacturing predictive of menstrual cycles as subclinical markers of female reproductive dysfunction effects of low-dose exposures. Methods: A total of 94 fabrication workers were followed for one complete menstrual cycle using daily urine samples: 23 were from the array, 53 from the panel, and 18 from the module work areas. The menstrual cycle characteristics of the study population were measured using a self-administered questionnaire. Urine samples were collected during the first urination in the morning for at least one complete menstrual cycle. The urine was then analyzed to determine the urinary concentrations of follicular stimulating hormone (FSH), estrone conjugates (E1C), and pregnanediol-3-glucuronide (PdG). The results of this analysis were used to assess the potential effects of chemical exposure as determined by handheld volatile organic compound (VOC) monitors and 24 h canisters. Results: The concentration of total VOCs was much higher in the module making area (ND-21,000 ppb) than in panel (ND-766 ppb) and array (58-1,472 ppb) making areas. The concentrations of ethanol and acetone were much higher in the module (1,974.9 and 2,283.2 ppb, respectively) and panel (2256.9 and 592.2 ppb, respectively) making areas. Compared to those in the array making area, we found that E1C (12.55, 95% confidence interval (CI): 8.49, 16.61 μg/mg Cr) and PdG (0.53, 95% CI: 0.29, 0.77 μg/mg Cr) levels in the module group were significantly higher in the early follicular phase; E1C (11.93, 95% CI: 6.21, 17.65 μg/mg Cr) and PdG (0.53, 95% CI: 0.29, 0.77 μg/mg Cr) levels were significantly higher in the periovulatory phase; and all the hormone levels, FSH (1.48, 95% CI: 0.81, 2.15 μg/mg Cr), E1C (9.29, 95% CI: 4.92, 13.66 μg/mg Cr), and PdG (1.01, 95% CI: 0.42, 1.60 μg/mg Cr) were also significantly higher in the luteal phase. In addition, the FSH (0.89, 95% CI: 0.07, 1.71 μg/mg Cr) level in the panel group was significantly higher but E1C (-4.49, 95% CI: -7.90, -1.08 μg/mg Cr) was lower in the early follicular phase; and E1C (-5.16, 95% CI: -9.61, -0.71 μg/mg Cr) level was significantly lower in the periovulatory phase. Conclusions: Our findings add to the evidence that exposure to multiple low-level chemicals is associated with modest changes in reproductive hormone urinary concentrations in healthy premenopausal women. In addition, the FSH (0.89, 95% CI: 0.07, 1.71 μg/mg Cr) level in the panel group was significantly higher but E1C (-4.49, 95% CI: -7.90, -1.08 μg/mg Cr) lower in the early follicular phase; and E1C (-5.16, 95% CI: -9.61, -0.71 μg/mg Cr) level was significantly lower in the periovulatory phase. ? 2013 by the authors; licensee MDPI, Basel, Switzerland.
SDGs
Other Subjects
acetone; alcohol; estrone conjugate; follitropin; pregnanediol 3 glucuronide; sex hormone; unclassified drug; volatile organic compound; acetone; concentration (composition); endocrine disruptor; estrogenic compound; ethanol; hormone; pollution effect; pollution exposure; reproductive health; urine; volatile organic compound; womens health; adult; article; concentration (parameters); female; female worker; human; industrial worker; industry; liquid crystal display manufacture; menstrual cycle; occupational exposure; premenopause; sex hormone determination; urinalysis; urine level; work environment
Type
journal article