The Effects of Short-Term Ozone Exposure on Echaled Volatile Organic Compounds
Date Issued
2006
Date
2006
Author(s)
Chen, Mong-Yun
DOI
zh-TW
Abstract
The purposes of this study were to investigate the effect of controlled ozone exposure for smokers and nonsmokers on the exhaled volatile organic compounds (VOCs), to compare the responses of ozone exposure between the two groups, and to evaluate whether exposure to ozone induced changes
in exhaled pentane, which serve as a biomarker of oxidative stress.
This study was a longitudinal study. Twenty volunteers (eight smokers and twelve nonsmokers),ages ranging from 20 to 30 years old, were exposed to 100 ppb of ozone for 2 hours. Subjects were exposed to ozone via a face-mask
inhalation system between 9:00 am and 12:00 am. Tedlar sampling bags were used to collect exhaled air before and after exposure at 5 minutes, 30 minutes, 4.5 hours and 22 hours. One liter of exhaled air in the sampling bags then was withdrawn by a sampling pump, and the VOCs in the exhaled air was collected using multi-bed sorbent traps and analyzed by Gas Chromatography/Mass Spectrometry. One hundred and seventeen VOCs were identified by a mass spectra library and were semiquantitatively analyzed.
Exhaled pentane level in smokers but not in nonsmokers, were increased 22 hours after ozone exposure. The level of exhaled sulphur-containing compounds thiobismethane and dimethyldisulfide in nonsmokers were immediately increased following ozone exposure whilst in smokers the levels
were increased only after 22 hours of ozone exposur. We suggested that smokers were more sensitive to ozone exposure than nonsmokers. Comparing the exhaled air VOCs from smokers and nonsmokers before ozone exposure, 17 compounds were significantly different between the two groups.
Subjects
呼出氣體分析
揮發性有機物
臭氧暴露氣相層析質譜儀
breath analysis
VOCs
ozone exposure
GC/MS
Type
thesis
File(s)![Thumbnail Image]()
Loading...
Name
ntu-95-R93844014-1.pdf
Size
23.31 KB
Format
Adobe PDF
Checksum
(MD5):5ac87ac742ad558cc6de70fc3d25102e