A dominant human leucocyte antigen DR4-Dw15 restricted mycobacterial 65KDa antigen-specific t-cell immunity in chinese patients with rheumatoid arthritis
Journal
Rheumatology
Journal Volume
34
Journal Issue
6
Pages
498-506
Date Issued
1995
Author(s)
Abstract
The human leucocyte antigen DR4-associated immune responses to Mycobacterium tuberculosis 65 kDa heat shock protein were considered to be relevant to the pathogenesis of rheumatoid arthritis (RA). In the Chinese population, DR4-Dwl5 was found to be the predominant DR4 subtype in RA. To further define the immune responses associated with DR4-Dwl5 molecules, the proliferative responses of peripheral (PBMC and synovial mononuclear cells (SFMC) to mycobacterial 65 kDa antigen were evaluated. The SFMC of all of our RA patients responded significantly to 65 kDa mycobacterial antigen. The responses of PBMC to this antigen in RA were much lower than those of SFMC. Our results further indicated that relatively low numbers of peripheral antigen-specific T-cells, but not incompetence of peripheral antigen presenting cells, might be related to the observed low responsiveness to 65 kDa antigen in PBMC of RA patients. Of utmost importance, DR4-Dwl5 was proved to be one of the major restrictive molecules in mycobacterial 65 kDa antigen-specific immune responses in Chinese RA patients. ? 1995 British Society for Rheumatology.
Subjects
65 kDa heat shock protein; Class II major histocompatibility; DR4-Dwl5; Mycobacterium tuberculosis; Rheumatoid arthritis
SDGs
Other Subjects
HLA DR4 antigen; mycobacterium antigen; adult; article; bacterial immunity; cellular immunity; chinese; clinical article; controlled study; female; human; male; mononuclear cell; mycobacterium tuberculosis; pathogenesis; priority journal; rheumatoid arthritis; synovium; t lymphocyte; Adult; Antigens, Bacterial; Arthritis, Rheumatoid; Cell Division; Chaperonins; Epitopes; Female; HLA-D Antigens; Human; Immunity; Male; Middle Age; Mongoloid Race; Monocytes; Reference Values; Reiter Disease; Support, Non-U.S. Gov't; Synovial Fluid; T-Lymphocytes
Type
journal article