Antioxidation and antiglycation of 95% ethanolic extracts prepared from the leaves of Solanum nigrum
Date Issued
2013
Date
2013
Author(s)
Hou, Tsung-Han
Abstract
Solanum nigrum are recently not only considered to be the brand-new source of functional ingredients that exerts antiglycation and anti-diabetes activities but also to be kind of medicinal food for improving blood glucose. However, there are only few identities of the active compounds and how those above-mentioned compounds counteract diabetes are still unknown. To induces insulin resistance occurs in an inflammatory response that requires the hyperglycemia results in the formation of advanced glycation end-products (AGEs). Evidence indicates that antioxidants can suppress the formation of reactive oxygen species, decrease levels of AGEs by inhibiting glycation. In this research demonstrates that 95% ethanolic extracts of Solanum nigrum exerted significant antioxidative activity compared with 50% ethanolic extracts and aqueous extracts. Moreover, 95% ethanolic extracts of S. nigrum produced antiglycative activity, which contributed to the inhibition of fructosamine and generation of α-dicarbonyl compounds. The results indicate that 95% ethanolic extracts of S. nigrum are with great bioactivities on antiglycation and anti-diabetes.
Subjects
最終醣化蛋白
抗氧化活性
龍葵
抗醣化作用
抗糖尿病
SDGs
Type
thesis
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