Efficacy of a mass hepatitis B immunization program after switching to recombinant hepatitis B vaccine: A population-based study in Taiwan
Journal
Vaccine
Journal Volume
19
Journal Issue
20-22
Pages
2825-2829
Date Issued
2001
Author(s)
Abstract
To study the efficacy of immunization against hepatitis B after plasma-derived vaccine was replaced by recombinant vaccine, 2-year-old Taiwanese children were recruited by stratification random sampling and tested for hepatitis B markers. They were grouped according to maternal infectivity and children's immunization status. Of 2010 children, 2.5% had hepatitis B surface antigen (HBsAg), 94.1% had its antibody (anti-HBs), 6.8% had core antibody, and 3.3% were seronegative. Children of highly infectious mothers immunized with hepatitis B immunoglobulin and vaccine on schedule had a lower HBsAg-positive rate and a higher anti-HBs-positive rate than those with vaccine only and off-schedule. The efficacy of the Taiwanese mass hepatitis B immunization was maintained after switching to recombinant hepatitis B vaccine. ? 2001 Elsevier Science Ltd.
Subjects
Efficacy; Mass immunization; Recombinant hepatitis B vaccine
SDGs
Other Subjects
h b vax ii; hepatitis B antibody; hepatitis B core antibody; hepatitis B core antigen; hepatitis B surface antibody; hepatitis B surface antigen; hepatitis B vaccine; recombinant hepatitis B vaccine; article; blood sampling; controlled study; drug efficacy; female; hepatitis B; Hepatitis B virus; high risk population; human; infection prevention; intrauterine infection; major clinical study; male; plasma; preschool child; preventive health service; priority journal; serology; Taiwan; treatment outcome; Child, Preschool; Female; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Humans; Immunization; Immunoglobulins; Male; Taiwan; Vaccines, Synthetic
Type
journal article