Increased heterogeneity of brain perfusion is an early marker of central nervous system involvement in antiphospholipid antibody carriers
Journal
PloS one
Journal Volume
12
Journal Issue
8
Pages
e0182344
Date Issued
2017
Author(s)
Lin, Ting-Syuan
Hsu, Pei-Ying
Chang, Chin-Hao
Hsein, Yenh-Chen
Abstract
The non-criteria neuropsychiatric manifestations of antiphospholipid syndrome include headache, dizziness, vertigo, seizure, depression and psychosis. There were still no objective methods qualified to detect the early central nervous system involvement in non-criteria antiphospholipid syndrome. We evaluated the effectiveness of Tc-99m ECD SPECT in assessing circulatory insufficiency in the brains of patients with antiphospholipid antibodies and neuropsychiatric symptoms but without thromboembolism.
Subjects
SUBARACHNOID HEMORRHAGE; CLASSIFICATION; PATHOGENESIS; DIAGNOSIS; THERAPY; EVENT; SPECT
SDGs
Other Subjects
cysteine ethyl ester tc 99m; phospholipid antibody; cysteine; cysteine ethyl ester tc 99m; phospholipid antibody; technetium complex; adult; antiphospholipid syndrome; Article; brain circulation; brain perfusion; central nervous system; controlled study; depression; diagnostic value; dizziness; female; headache; human; imaging system; major clinical study; male; mental disease; psychosis; seizure; single photon emission computed tomography; thromboembolism; vertigo; analogs and derivatives; antiphospholipid syndrome; blood; brain; brain circulation; central nervous system; complication; diagnostic imaging; middle aged; neurologic disease; pathophysiology; retrospective study; single photon emission computed tomography; Adult; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Brain; Central Nervous System; Cerebrovascular Circulation; Cysteine; Female; Humans; Male; Mental Disorders; Middle Aged; Nervous System Diseases; Organotechnetium Compounds; Retrospective Studies; Thromboembolism; Tomography, Emission-Computed, Single-Photon
Publisher
PUBLIC LIBRARY SCIENCE
Type
journal article