Anatomic and functional characteristics of the rat ileal pouch
Journal
American Journal of Surgery
Journal Volume
183
Journal Issue
4
Pages
464-470
Date Issued
2002
Author(s)
Abstract
The definitive operation for chronic ulcerative colitis (UC) and familial adenomatous polyposis is total proctocolectomy with ileal pouch-anal anastomosis (IPAA). Mild inflammation (pouchitis) is omnipresent in pouches and becomes severe in 50% of UC patients with IPAA. The etiology of pouchitis is likely due to combined genetic, microbial, and immunologic factors. Epithelial cell exposure to surgical trauma and/or to changes in intestinal bacterial composition may account for the inflammatory infiltrate. Progress in understanding pouchitis is restricted by the lack of suitable animal models. An ileal pouch-rectal anastomosis [IPRA] in rats was developed to reproduce a model of human IPAA and clinical, gross and histologic criteria were determined. Many shared features with human ileal pouch were observed. IPRA is an important in vivo model to study mechanisms of repair, defense and immunity that may contribute to pouchitis.
SDGs
Type
journal article