Oxygenated Terpenoids from a Formosan Soft Coral Sinularia gibberosa
Resource
Journal of Natural Products 68 (8): 1208-1212
Journal
Journal of Natural Products
Journal Volume
68
Journal Issue
8
Pages
1208-1212
Date Issued
2005
Date
2005
Author(s)
Abstract
Three new oxygenated sesquiterpenoids, gibberodione (1), peroxygibberol (2), and sinugibberodiol (3), along with sarcophytol L (4) were isolated from a Formosan soft coral, Sinularia gibberosa. The structures of the new metabolites were determined on the basis of extensive spectroscopic analyses and by comparison of NMR data with those of related metabolites. Metabolites 2 and 4 were found to exhibit moderate cytotoxicity toward a human liver carcinoma cell line. ? 2005 American Chemical Society and American Society of Pharmacognosy.
Other Subjects
gibberodione; peroxygibberol; sarcophytol L; sesquiterpenoid; sinugibberodiol; unclassified drug; article; cancer cell culture; cancer inhibition; carbon nuclear magnetic resonance; cell strain KB; controlled study; coral; cytotoxicity; drug isolation; drug structure; human; human cell; liver carcinoma; nuclear Overhauser effect; proton nuclear magnetic resonance; Taiwan; Animals; Anthozoa; Antineoplastic Agents; Drug Screening Assays, Antitumor; Humans; KB Cells; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oxygen; Sesquiterpenes; Tumor Cells, Cultured; Alcyonacea; Sinularia
Type
journal article
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