Incidence of Internal Cancers and Ingested Inorganic Arsenic: A Seven-Year Follow-up Study in Taiwan
Journal
Cancer Research
Journal Volume
55
Journal Issue
6
Pages
1296-1300
Date Issued
1995
Author(s)
Chiou H.-Y.
Hsueh Y.-M.
Liaw K.-F.
Horng S.-F.
Chiang M.-H.
Chen C.-J.
Chiou H.-Y.
Hsueh Y.-M.
Lin J.S.-N.
Huang C.-H.
Chen C.-J.
Abstract
In order to elucidate the dose-response relationship between ingested inorganic arsenic and internal cancers, a total of 263 patients with black-foot disease and 2293 healthy residents in the endemic area of arseniasis were recruited and followed up for 7 years. The information on consumption of high-arsenic artesian well water, sociodemographic characteristics, life-style and dietary habits, and personal and family history of cancers was obtained through standardized interviews. The occurrence of internal cancers among study subjects was determined through annual health examinations, home visit personal interviews, household registration data checks, and national death certification and cancer registry profile linkages. A dose-response relationship was observed between the long-term arsenic exposure from drinking artesian well water and the incidence of lung cancer, bladder cancer, and cancers of all sites combined after adjustment for age, sex, and cigarette smoking through Cox's proportional hazards regression analysis. Blackfoot disease patients had a significantly increased cancer incidence after adjustment for cumulative arsenic exposure. ? 1995, American Association for Cancer Research. All rights reserved.
SDGs
Other Subjects
arsenic; well water; article; blackfoot disease; bladder cancer; cancer incidence; cancer risk; case control study; controlled study; female; human; lung cancer; major clinical study; male; priority journal; risk factor; water contamination; Arsenic; Bladder Neoplasms; Female; Follow-Up Studies; Human; Incidence; Lung Neoplasms; Male; Neoplasms; Peripheral Vascular Diseases; Support, Non-U.S. Gov't; Taiwan; Time Factors; Water Pollutants, Chemical
Type
journal article