肺癌醣化酵素基因異常調控之研究(1/3)
Other Title
Dysregulation of Glycosyltransferase Genes in Lung Cancer
Date Issued
2003
Date
2003
Author(s)
余忠仁
DOI
912314B002268
Abstract
Mucins and mucin associated antigens are believed to play an important role in
both invasion and metastasis of cancer cells. The altered expression of mucin peptides
in cancer cells, as well as glycosylation, facilitates tumor cell invasion into blood
stream, attachment to endothelial cells and escape from host immuno-surveillance. Our previous studies had demonstrated the prognostic implication of mucin
expression for lung cancer. Lung cancers overexpressing sialomucins tend to have
higher chance of recurrence and metastasis. The expression of sialomucin is
correlated with the overexpression of an oncoprotein, erbB-2/neu, and at least one
mucin gene ( MUC5AC apomucin). We are than interested about the altered
expression of glycosyltransferase genes in lung cancer. Preliminarily, using multiplex
PCR to evaluate the expression of sialyltransferase(ST) and fucosyltransferase (FucT)
gene families in lung cancer (in >50% of patients), we have demonstrated that
overexpression of STs and FucTs are common in lung cancer tissues and cell lines.
Daughter cell line (CL1-5) with high invasiveness and metastasis ability expressed
more STs and FucTs than parent cell line (CL1-0 and CL1-1). Clinically, patients
bearing tumors with overexpression of ST3GalIII and FucTIII 、IV 、VI 、VII are liable
to cancer recurrence and death. We thus propose a three-year study to
comprehensively study the role of glycosyltransferase genes expression in lung cancer.
Is up-regulation or down-regulation of certain glycosyl -transferase which leads to
expression of cancer-associated sialylated antigens occurs preferentially in lung
cancer? Can the altered expression of glycosyltransferase genes serve as a prognostic
marker? Specific glycosyltransferase genes considered to be important in lung cancers
will be cloned and subjected to further study. In the first year, we evaluated the
expression of N-acetyl -glucosaminyltransferase (MGAT) I~V in lung cancer and the
association of MGAT expression with clinical features and prognosis of lung cancer.
Subjects
Lung cancer
glycosyltransferase
SDGs
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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