Intercellular Calcium Waves and Permeability Change Induced by Vertically Deployed Surface Acoustic Waves in a Human Cerebral Microvascular Endothelial Cell Line (hCMEC/D3) Monolayer
Journal
Ultrasound in medicine & biology
Journal Volume
49
Journal Issue
5
Date Issued
2023-05
Author(s)
Abstract
The ultrasound-mediated blood-brain barrier (BBB) opening with microbubbles has been widely employed, while recent studies also indicate the possibility that ultrasound alone can open the BBB through a direct mechanical effect. However, the exact mechanisms through which ultrasound interacts with the BBB and whether it can directly trigger intracellular signaling and a permeability change in the BBB endothelium remain unclear.
Subjects
Blood–brain barrier; Calcium wave; Endothelial cells; Ultrasound
SDGs
Type
journal article