Statin Use Is Associated With Improved Prognosis of Colorectal Cancer in Taiwan
Journal
Clinical Colorectal Cancer
Pages
177-184.e4
Date Issued
2015
Date
2015
Author(s)
Chen H.-M.
Yeh Y.-C.
Lai C.-L.
Lai M.-S.
Abstract
We established a population-based cohort of patients who received curative surgery for stage I, II, or III colorectal cancer. Among 17,115 patients included in this study, we found that statin use was an independent predictor for longer cancer-specific survival and overall survival in multivariate analysis after adjusting for other potential prognostic factors. These associations were consistent across subgroups. ;Background: Statins are widely used for hyperlipidemia control and might also exhibit anticancer properties. This study explored whether statin use is associated with the prognosis of curatively resected colorectal cancer (CRC). Materials and Methods: Using data from the Taiwan Cancer Registry, we established a population-based cohort of patients who received curative surgery for stage I, II, or III CRC. Data related to prescription medications and comorbidities were retrieved from the database of the National Health Insurance program of Taiwan. Statin users were defined as patients who had used statins within 1 year before their cancer diagnosis. Univariate and multivariate analyses were used to compare cancer-specific survival (CSS) and overall survival (OS) between statin users and patients who had never used statins (never users). In the multivariate analysis, we used propensity scores to adjust for age, sex, diagnosis year, physician visits, hospitalization, conjunctive medications, and comorbidities. Results: A total of 17,115 patients were enrolled; 2145 (13%) of these patients were statin users, and 14,970 (87%) were never users. After adjusting for other potential prognostic factors, statin use was an independent predictor for longer CSS (hazard ratio [HR], 0.77; 95% confidence interval [CI], 0.68-0.88; P < .001) and OS (HR, 0.82; 95% CI, 0.74-0.92; P < .001). These associations were consistent across subgroups, including sexes, tumor stages, and age cohorts, and in CRC patients who suffered from diabetes and hypertension. Conclusion: Statin use is associated with an improved prognosis of curatively resected CRC.
Subjects
Colon cancer
Database analysis
National Health Insurance
Rectal cancer
Survival
SDGs
Other Subjects
antineoplastic agent; hydroxymethylglutaryl coenzyme A reductase inhibitor; hydroxymethylglutaryl coenzyme A reductase inhibitor; adjuvant chemoradiotherapy; aged; Article; cancer chemotherapy; cancer patient; cancer prognosis; cancer radiotherapy; cancer registry; cancer specific survival; cancer staging; cancer surgery; Charlson Comorbidity Index; cohort analysis; colorectal cancer; comorbidity; drug use; female; follow up; human; hydrophilicity; major clinical study; male; medical record review; multimodality cancer therapy; national health insurance; outcome assessment; overall survival; prescription; Taiwan; Colorectal Neoplasms; factual database; middle aged; multivariate analysis; pathology; prognosis; register; survival rate; Aged; Colorectal Neoplasms; Databases, Factual; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Multivariate Analysis; Neoplasm Staging; Prognosis; Registries; Survival Rate; Taiwan