Sparing Immunosuppression in Heart Transplant Recipients With Severe Sepsis
Journal
Transplantation Proceedings
Journal Volume
38
Journal Issue
7
Pages
2145-2146
Date Issued
2006
Author(s)
Ko W.J.
Lin F.Y.
Chu S.H.
Abstract
This study described an analysis of severe sepsis among heart transplantation recipients who were treated by sparing all immunosuppressants. Sepsis leading to multiple organ failure (MOF) in heart transplantation has a high mortality. This retrospective study of 190 patients who underwent heart transplantation from 1993 to 2004 included 12 who had severe sepsis with MOF who were treated by sparing all immunosuppressants. Half of them survived after sparing all immunosuppressants with intensive endomyocardial biopsy. Only one case needed pulse therapy for an acute rejection episode. The most common bacterial infectious episodes were caused by methicillin-resistant Staphylococcus aureus (n = 3). All sepsis episodes occurred in the first month after heart transplantation except in one case, which occurred 6 years after heart transplantation. There was a 50% survival rate of heart transplantation recipients who experienced MOF due to severe sepsis and were treated by sparing all immunosuppressants under a program of intensive endomyocardial biopsy. ? 2006 Elsevier Inc. All rights reserved.
SDGs
Other Subjects
cefazolin; immunosuppressive agent; nystatin; steroid; article; bacterial infection; cardiac graft rejection; drug pulse therapy; graft recipient; heart muscle biopsy; heart transplantation; human; human tissue; major clinical study; methicillin resistant Staphylococcus aureus; mortality; multiple organ failure; oropharynx candidiasis; postoperative complication; priority journal; retrospective study; sepsis; survival rate; Bacterial Infections; Candidiasis; Dose-Response Relationship, Drug; Heart Transplantation; Humans; Immunosuppressive Agents; Multiple Organ Failure; Retrospective Studies; Sepsis
Type
journal article
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