LTBP4 Protects Against Renal Fibrosis via Mitochondrial and Vascular Impacts
Journal
Circulation research
Journal Volume
133
Journal Issue
1
Date Issued
2023-06-23
Author(s)
See, Daniel H W
Huang, Yue-Jhu
Liu, Shin-Yun
Chou, Chih-Yi
Abstract
As a part of natural disease progression, acute kidney injury (AKI) can develop into chronic kidney disease via renal fibrosis and inflammation. LTBP4 (latent transforming growth factor beta binding protein 4) regulates transforming growth factor beta, which plays a role in renal fibrosis pathogenesis. We previously investigated the role of LTBP4 in chronic kidney disease. Here, we examined the role of LTBP4 in AKI.
Subjects
angiogenesis; chronic kidney disease; latent transforming growth factor beta binding protein 4; mitochondrial function; renal fibrosis
SDGs
Type
journal article