Glutathione S-transferase polymorphisms associated with risk of breast cancer in southern Taiwan
Journal
Breast
Journal Volume
15
Journal Issue
6
Pages
754-761
Date Issued
2006
Author(s)
Abstract
In this study, the genetic polymorphisms associated with breast cancer in southern Taiwan were investigated. Two categories of genes were analyzed: (1) BRCA1, BRCA2, and Rad51, the DNA repair factors involved in homologous recombinational repair; and (2) CYP1A1, COMT, GST, and NAT2, the xenobiotic-metabolizing enzymes (XME) involved in estrogen metabolism. We found that the number of deletions and/or mutations in the GST genes was highly correlated with the occurrence of breast cancer. These data suggest that the GST enzymes, which detoxify the catechol estrogen quinones, are important target molecules for screening in populations at high risk of breast cancer.
SDGs
Publisher
Churchill Livingstone
Type
journal article