Nanoparticles in the treatment of infections caused by multidrug-resistant organisms
Journal
Frontiers in Pharmacology
Journal Volume
10
Pages
1153
Date Issued
2019
Author(s)
Abstract
Nanotechnology using nanoscale materials is increasingly being utilized for clinical applications, especially as a new paradigm for infectious diseases. Infections caused by multidrug-resistant organisms (MDROs) are emerging as causes of morbidity and mortality worldwide. Antibiotic options for infections caused by MDROs are often limited. These clinical challenges highlight the critical demand for alternative and effective antimicrobial strategies. Nanoparticles (NPs) can penetrate the cell membrane of pathogenic microorganisms and interfere with important molecular pathways, formulating unique antimicrobial mechanisms. In combination with optimal antibiotics, NPs have demonstrated synergy and may aid in limiting the global crisis of emerging bacterial resistance. In this review, we summarized current research on the broad classification of the NPs that have shown in vitro antimicrobial activity against MDROs, including the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species). The pharmacokinetics and pharmacodynamic characteristics of NPs and bacteria-resistant mechanisms to NPs were also discussed. Copyright ? 2019 Lee, Ko and Hsueh.
SDGs
Other Subjects
aluminum nanoparticle; aluminum oxide nanoparticle; ampicillin; antiinfective agent; ceftazidime; ciprofloxacin; clindamycin; copper nanoparticle; erythromycin; gold nanoparticle; iron oxide; kanamycin; magnesium oxide nanoparticle; nanoparticle; polymyxin B; quinolone derivative; silica nanoparticle; silver nanoparticle; streptomycin; tetracycline; titanium dioxide nanoparticle; ultrasmall superparamagnetic iron oxide; unclassified drug; vancomycin; Acinetobacter baumannii; antibacterial activity; antibiotic resistance; bacterial strain; bacterium; bacterium isolate; biocompatibility; bone marrow toxicity; colon disease; concentration response; drug absorption; drug clearance; drug conjugation; drug delivery system; drug elimination; drug mechanism; drug penetration; drug potentiation; Enterobacter; Enterococcus faecium; Escherichia coli infection; human; immune response; in vitro study; Klebsiella pneumoniae; liver injury; liver toxicity; lung injury; lymphatic system disease; membrane potential; methicillin resistant Staphylococcus aureus; minimum inhibitory concentration; multidrug resistance; multidrug resistance organism; multidrug resistant Escherichia coli; nephrotoxicity; neurotoxicity; nonhuman; particle size; physical chemistry; protein synthesis; Pseudomonas aeruginosa; Review; RNA synthesis; spleen disease; spleen injury; Staphylococcus aureus; surface charge; surface property; vancomycin resistant Enterococcus; zeta potential
Type
review