Renal manifestations in Henoch-Schönlein purpura: A 10-year clinical study
Journal
Pediatric Nephrology
Journal Volume
20
Journal Issue
9
Pages
1269-1272
Date Issued
2005
Author(s)
Abstract
Henoch-Sch?nlein purpura (HSP) is an IgA-mediated systemic small vessel vasculitis of childhood. It is characterized by the symptoms including nonthrombocytopenic purpura, abdominal pain, hematuria/ proteinuria, and arthargia/arthritis. We conducted a retrospective study of 261 patients diagnosed with HSP from December 1991 to December 2001. Of the 261 patients, fifty-three (20.3%) developed renal manifestations after onset of the disease. Two patients developed nephrotic syndrome. Four patients had group A beta-hemolytic streptococcal pharyngitis and subsequent depressed serum C3 concentration typical of post streptococcal glomerulonephritis. During the study period, the renal survival rate after disease onset was 100%. The prognosis of renal involvement was better than reports from other series. In this study we also found factors associated with HSP nephritis; these included older age at onset, GI bleeding, and central nervous system involvement. The long-term morbidity of HSP is predominantly attributed to renal involvement. It is thus recommended that patients with HSP nephritis are followed for longer periods of time. ? IPNA 2005.
SDGs
Other Subjects
immunoglobulin A; abdominal pain; adolescent; adult; anaphylactoid purpura; arthralgia; arthritis; article; central nervous system disease; child; clinical feature; clinical study; controlled study; female; follow up; gastrointestinal hemorrhage; glomerulonephritis; human; kidney disease; major clinical study; male; melena; morbidity; nephrotic syndrome; onset age; pharyngitis; priority journal; prognosis; retrospective study; Streptococcus group A; survival rate; Adolescent; Adult; Child; Child, Preschool; Female; Humans; Infant; Male; Nephritis; Purpura, Schoenlein-Henoch; Retrospective Studies
Type
journal article