Defining the causes of sporadic Parkinson's disease in the global Parkinson's genetics program (GP2)
Journal
NPJ Parkinson's disease
Journal Volume
9
Journal Issue
1
Pages
131
Date Issued
2023-09-12
Author(s)
Towns, Clodagh
Richer, Madeleine
Jasaityte, Simona
Stafford, Eleanor J
Joubert, Julie
Antar, Tarek
Martinez-Carrasco, Alejandro
Makarious, Mary B
Casey, Bradford
Vitale, Dan
Levine, Kristin
Leonard, Hampton
Pantazis, Caroline B
Screven, Laurel A
Hernandez, Dena G
Wegel, Claire E
Solle, Justin
Nalls, Mike A
Blauwendraat, Cornelis
Singleton, Andrew B
Tan, Manuela M X
Iwaki, Hirotaka
Morris, Huw R
Abstract
The Global Parkinson's Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia.
SDGs
Type
journal article