The Design and Application of Enriched Hyperpolarized 129 Xe in 3T-MRI
Date Issued
2009
Date
2009
Author(s)
Liu, Yuan-Fu
Abstract
Magnetic resonance imaging (MRI) is a non-invasive imaging system, and it’s an important technique in modern medicine. Traditional MRI is not able to acquire images in a cavity of body. Therefore, some experiments use the hyperpolarized gas as the signal source. Most researches in magnetic resonance image of different nucleon use 3 He, because hyperpolarized 3 He provided better signal to noise ratio with high degree of polarization. 3 He and 129 Xe are inert gases that do not cause biological effects to human body. The signal of hyperpolarized gas can be increased by more than thousand or ten thousand times. Although129 Xe is abundant in the nature, its lower degree of hyperpolarization limits its applications in MR; the signal to noise ratio (SNR) of image is relatively low. In this article, the gas containing approximately 85% of enriched 129 Xe was used to overcome this problem for better MR images. A batch pumping process of producing enriched HP-129 Xe had been set up. The design of optical pumping cell, which is the container for hyperpolarized process, isery crucial. We combine the laser device, heating device, magnetic system and delivery device to produce steady hyperpolarized gas. In addition, we designed and implemented the dual frequency coil suited for 129 Xe and proton to avoid misregistration.he enriched HP-129 Xe was characterized in 3T-MRI. The peak signal intensity of hyperpolarized gas we produced can increase 1300 times approximately by using this technology. In the batch pumping process system, the phantom images showed that the SNR is 2~4 relative to the continuous system. The gas delivery system was also set up that we can detect the signal of 129 Xe in vivo. In the Future, with better integrate hyperpolarized MR system; we are expecting to acquire the lung imaging in human body.
Subjects
magnetic resonance image
hyperpolarized
optical pumping
SDGs
Type
thesis
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