Mullerian adenosarcoma: a review of cases and literature
Resource
Eur. J. Gynaecol. Oncol., 35(6), 617-620
Journal
Eur. J. Gynaecol. Oncol.
Journal Volume
35
Journal Issue
6
Pages
617-620
Date Issued
2014
Date
2014
Author(s)
Huang, P. S.
Chang, W. C.
Huang, S. C.
Abstract
Objective: Mullerian adenosarcoma usually originates in the endometrium and grows as a polypoid mass in post-menopausal women presenting as abnormal vaginal bleeding. This report reviewed Mullerian adenosarcoma cases to clarify the clinical and pathologic characteristics. Materials and Methods: Fifteen cases of Mullerian adenosarcoma in two medical centers covering a 15-year period were reviewed. Their clinical characteristics, pathologic findings, treatment, and outcomes were compared. Results: Of the 15 cases, three originated from the endometrium, six arose from uterine adenomyosis, three from the adnexa, and three from the cervix. There was only one post-menopausal case. One case was of breast cancer with tamoxifen (TMX) therapy. There were four Mullerian adenosarcoma with sarcomatous overgrowth (MASO) cases, three of which died within one year after surgery. Only the focal MASO case survived. Conclusion: The rare variant of MASO is very aggressive and associated with poor prognosis.
Subjects
Adenomyosis
Mullerian adenosarcoma with sarcomatous overgrowth
Tamoxifen
SDGs