Chromosomal abnormalities of 200 Chinese patients with non-Hodgkins's lymphoma in Taiwan: With special reference to T-cell lymphoma
Journal
Annals of Oncology
Journal Volume
15
Journal Issue
7
Pages
1091-1096
Date Issued
2004-11
Author(s)
Wang C.-C.
Su I.-J.
Lee F.-Y.
Liu M.-C.
Abstract
Background: The distribution of the histopathological subtypes of non-Hodgkin's lymphoma (NHL) is different among various geographical areas. However, there are few reports concerning cytogenetic findings of NHL, especially T-cell lymphoma, in Asian people. Patients and methods: We analyzed the chromosomal abnormalities of 200 adult patients with NHL in Taiwan and correlated the non-random aberrations with the histological subtypes. Results: One hundred and thirty-eight patients (69%) had B-cell lymphoma. The incidence of the t(14;18) in total lymphoma was lower in Taiwan (12%) than in the West (20-30%), but its incidence in follicular lymphoma was comparable between the two areas (17 of 28 patients, 61% versus ?50-60%). Sixty-two patients (31%) had T-cell lymphoma, including 11 angiocentric T/natural killer (NK)-cell lymphoma and only two angioimmunoblastic T-cell lymphoma (AILD). The recurrent chromosomal abnormalities in T-cell lymphoma comprised 6q deletion (30%), 11q deletion (20%), 17p deletion (16%), -17 (16%), -Y (14%) and + 8 (11%). Angiocentric T/NK-cell lymphoma had a significantly higher frequency of 1q duplication (P=0.001), 6p duplication (P<0.001) and 11q deletion (P = 0.011) than other T-cell lymphoma. The incidences of + 3 and + 5, two common abnormalities in AILD, were quite low in T-cell lymphoma in Taiwan (4% and 2%, respectively), compared with those in the West (16-32% and ?15%, respectively). The 11q deletion, not a common aberration in T-cell lymphoma in western countries, occurred quite frequently in Taiwan. Conclusions: The chromosomal aberrations of NHL are quite different among various geographical areas, which may reflect the differences in the distribution of the histological subtypes of lymphoma among various areas. ? 2004 European Society for Medical Oncology.
SDGs
Other Subjects
adult; aged; article; Asia; B cell lymphoma; cancer classification; cancer incidence; cancer recurrence; Chinese; chromosome 11q; chromosome 17p; chromosome 1q; chromosome 6p; chromosome aberration; chromosome duplication; controlled study; correlation analysis; cytogenetics; ethnic difference; gene deletion; geographic distribution; histopathology; human; human tissue; major clinical study; natural killer cell; nonhodgkin lymphoma; priority journal; T cell lymphoma; Adult; Aged; Aged, 80 and over; Bone Marrow Cells; Chromosome Aberrations; Chromosome Deletion; Gene Duplication; Humans; Karyotyping; Lymph Nodes; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Middle Aged; Taiwan
Type
journal article