Non-invasive photobiomodulation using near-infrared photon irradiation to alleviate amyloid-beta aggregation in Alzheimer’s disease
Journal
Microchemical Journal
Journal Volume
215
ISSN
0026-265X
Date Issued
2025-08
Author(s)
Huang, Wen-Tse
Chan, Ming-Hsien
Satpathy, Aishwarya
Su, Ting-Yi
Chiu, Chien-Jung
Lu, Kuang-Mao
Hsieh, Wen-Yu
Chen, Bi-Chang
Hsiao, Michael
Abstract
Near-infrared (NIR) applications have attracted researchers’ attention in recent years. Particularly in non-invasive treatment, NIR photons can activate the receptor in mitochondria and modulate through multiple pathways. As a safe and low-cost light source, a light-emitting diode (LED) opens new possibilities for NIR photobiomodulation (PBM). In this study, 770 and 810 nm LEDs are used as light sources to alleviate the symptoms of Alzheimer's Disease. The penetration ability of NIR-LEDs is verified in ex vivo and in vivo experiments and by simulated energy distribution with the Monte Carlo method. Mitochondrial abnormalities are associated with the progression and worsening of Alzheimer's disease, which fail to mitigate the appearance of abnormal plaques and neurofibrillary tangles in the brain. This research utilizes PBM to activate mitochondria, aiming to reduce the excessive accumulation of amyloid beta. Furthermore, behavioral pattern and staining assessments were conducted to evaluate the amyloid beta aggregation in APP/PS1 mice. After one and two-stage treatments, the improvement in animal behavior can be observed at 45 % and 72 %, respectively. Amyloid-beta aggregates also present a significant reduction (∼63 %–87 %) in the brain imaging system. The safety of NIR-LEDs is confirmed by cell viability with SH-SY5Y cells. NIR-LED not only makes the light source more accessible but also provides adjuvant therapeutic effects and safety under PBM treatment.
Subjects
Alzheimer's disease
Amyloid-beta
Mouse behavioral pattern
Near-infrared light-emitting diode
Photobiomodulation
Publisher
Elsevier BV
Type
journal article