Usefulness of whole body positron emission tomography (PET) with 18F-fluoro-2-deoxyglucose (FDG) to detect recurrent ovarian cancer based on asymptomatically elevated serum levels of tumor marker (CA-125 antigen)
Journal
Neoplasma
Journal Volume
49
Journal Issue
5
Pages
329-333
Date Issued
2002
Author(s)
Abstract
The aim of this study was to evaluate practice usefulness of whole body positron emission tomography (PET) with 18F-fluoro-2- deoxyglucose (FDG) to detect recurrent ovarian cancer based on asymptomalically elevated tumor marker (CA-125) serum levels. Whole-body FDG-PET was performed in 28 patients with suspected recurrent ovarian cancers and asymptomatically increased serum levels of tumor marker (CA-125 antigen) but negative or equivocal other imaging modality results. All of these 28 asymptomatic patients had serum levels of CA-125 antigen >35 U/ml. The final diagnosis of recurrent ovarian cancer was established by operation/biopsy histopathological findings or clinical follow-up longer than 1 year by additional morphologic imaging techniques. Among the 28 patients, the final diagnoses of recurrent ovarian cancers and benign lesions were established in 20 and 8 patients, respectively. FDG-PET accurately diagnosed recurrent ovarian cancers in 19 patients and benign lesions in 7 patients. When asymptomatically elevated serum levels of CA-125 antigen, the diagnostic sensitivity, specificity, and accuracy of FDG-PET to detect recurrent ovarian cancers were 95.0%, 87.5%, and 92.9%, respectively. FDG-PET is a useful technique to detect recurrent ovarian cancers for patients suspected of recurrent ovarian cancers due to asymptomatically elevated serum levels of CA-125 antigen.
Subjects
18F-fluoro-2-deoxyglucose (FDG); Ovarian cancer; Positron emission tomography (PET); Tumor marker (CA-125)
SDGs
Other Subjects
CA 125 antigen; fluorodeoxyglucose f 18; adult; aged; article; blood analysis; cancer diagnosis; clinical article; controlled study; diagnostic accuracy; diagnostic procedure; female; follow up; histopathology; human; ovary cancer; positron emission tomography; radiodiagnosis; recurrent cancer
Type
journal article