高劑量tetrahydrobiopterin對發炎反應以及nitric oxide及自由基產生之影響
Date Issued
2005
Date
2005
Author(s)
胡務亮
DOI
932314B002131
Abstract
Tetrahydrobiopterin (BH4) is an essential cofactor for the nitric oxide synthases (NOSs). BH4 is
currently increasingly considered as a treatment module for a variety of conditions. We studied the
effect of high-dose BH4 on the production of nitric oxide (NO) and free radicals during inflammation.
In mice, lipopolysaccharide (LPS) triggered the production of NO, superoxide, and peroxynitrite.
Surprisingly, intra-peritoneal injection of BH4 at a dosage of 100-150mg/kg suppressed the production
of NO and the free radicals. In RAW264.7 cells treated with LPS and IFN-BH4 at a concentration of
500-750M suppressed the production of NO, but did not alter the induction of iNOS mRNA. However,
BH4 severely shortened the half-life of iNOS protein, and dramatically decreased the steady state iNOS
protein level. Therefore, BH4 could be a potential treatment to lower down the production of NO and
free radicals during acute inflammation.
Publisher
臺北市：國立臺灣大學醫學院小兒科
Type
report
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