Exploring the mechanism of radiation-enhanced hepatocellular carcinoma cell invasion by swept source optical coherence tomography
Journal
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Journal Volume
7889
Date Issued
2011
Author(s)
Abstract
Ionizing radiation is a standard treatment for various human solid tumors. However, several clinical studies showed that a significant proportion of patients undergoing radiotherapy for hepatocellular carcinoma (HCC) develop intrahepatic and extrahepatic metastasis. Understanding of radiation-induced cancer cell invasiveness and behavior is essential and of great important for developing suitable treatment strategies to contain cancer spread. Therefore, in this study we evaluated the effectiveness of using swept source optical coherence tomography (SS-OCT) to monitor the enhancement of HCC cell invasiveness by radiation. SS-OCT images were acquired and recorded to obtain three-dimensional data sets per four hours in 48 hours after irradiating HepG2 cells with 7.5 Gy. The cell migration behavior in three-dimensional tissue models was quantified from images of radiation-induced and sham-irradiated cells. ? 2011 Copyright SPIE - The International Society for Optical Engineering.
Subjects
hepatocellular carcinoma; radiation-enhanced cell invasion; swept source optical coherence tomography
SDGs
Other Subjects
Cell migration; Clinical study; Hepatocellular carcinoma; Hepatocellular carcinoma cell; HepG2 cells; Invasiveness; Radiation-induced; Radiation-induced cancer; Solid tumors; Swept source optical coherence tomographies; Three-dimensional data; Tissue models; Cytology; Diseases; Ionizing radiation; Three dimensional; Tomography; Radiotherapy
Type
conference paper