The detectability and reliability of vitamin C detection in human brain using standard 1H spectroscopy on a clinical 3T MR-system
Date Issued
2009
Date
2009
Author(s)
Shih, Yi-Yu
Abstract
Magnetic resonance spectroscopy (MRS) has been used in clinical applications, especially in brains, for many years. Even though vitamin C plays an important role in central nervous system, its analysis was not included in traditional MRS studies. To evaluate whether vitamin C is detectable, we used a clinical routine MRS sequence, point-resolved spectroscopy (PRESS), combined LCModel analysis, and verified the reliability of its estimated concentration. Seventy-six in vivo single voxel spectra were analyzed and vitamin C could be successfully detected from most of them. Furthermore, we simulated multiple concentration levels by adding adapted ascorbate spectra to the in vivo data, and the results showed very good linearity (R2 > 0.985) between the added ascorbate concentrations and the LCModel estimated concentrations at three different linewidth cases. This dissertation demonstrates the ability to detect vitamin C in the human brain under common clinical MRS standards in combination with LCModel. Besides, it also supports the necessity to include ascorbate in the standard MRS analysis.
Subjects
vitamin C spectrum
clinical MRS
traditional PRESS
LCModel
Type
thesis
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