Bioactive cembranoids from the dongsha atoll soft coral Sarcophyton crassocaule
Journal
Marine Drugs
Journal Volume
9
Journal Issue
6
Pages
994-1006
Date Issued
2011
Author(s)
Abstract
Seven new cembranoids, sarcocrassocolides F-L (1-7), have been isolated from a soft coral Sarcophyton crassocaule. Their structures were determined by extensive spectroscopic analysis. Most new compounds exhibited significant cytotoxic activity against a limited panel of cancer cell lines, and the structure-activity relationship was studied. Compounds 1-7 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Compound 4 was also found to effectively reduce the level of COX-2 protein. ? 2011 by the authors.
Subjects
Anti-inflammatory activity; Cytotoxic activity; Sarcophyton crassocaule; Soft coral
Other Subjects
cembranoid; cyclooxygenase 2; inducible nitric oxide synthase; mitomycin C; sarcocrassocolide F; sarcocrassocolide G; sarcocrassocolide H; sarcocrassocolide I; sarcocrassocolide J; sarcocrassocolide K; sarcocrassocolide L; unclassified drug; antiinflammatory activity; article; cancer cell culture; controlled study; coral; drug cytotoxicity; drug isolation; drug structure; human; human cell; in vitro study; macrophage; nonhuman; protein expression; Sarcophyton crassocaule; structure activity relation; Alcyonacea; Sarcophyton crassocaule
Type
journal article