Platinum(II) Drug-Loaded Gold Nanoshells for Chemo-Photothermal Therapy in Colorectal Cancer
Journal
ACS Applied Materials and Interfaces
Journal Volume
12
Journal Issue
4
Pages
4254-4264
Date Issued
2020
Author(s)
Lee S.-Y.
Abstract
In the present study, we utilize a poly[2-(N,N-dimethylamino)ethyl methacrylate]-poly(?-caprolactone) (PDMA-PCL) micellar template-based gold nanoshell as a nanocarrier of a platinum-based chemotherapeutic drug, dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt). The gold nanoshells not only function as a drug delivery platform but also provide a remarkable photothermal effect, resulting in synergistically combined chemo-photothermal therapy. With the positively charged outstretched hydrophilic PDMA segments, chloroauric anions are attracted to the PDMA-PCL micellar surface and reduced to gold atoms in situ, forming small seeds that nucleate the subsequent growth of gold nanoshells. The DACHPt-loaded gold nanoshells possess strong absorption in the near-infrared (NIR) region and outstanding photothermal conversion effect; thus, they can promote a temperature increase that is sufficient to ablate tumor cells under NIR laser irradiation at a moderate power density (1 W/cm2). Furthermore, by exploiting the synergistic effects of platinum-based chemotherapy and photothermal therapy, the DACHPt-loaded gold nanoshells exhibited a profound inhibition of tumor growth compared to chemotherapy or photothermal therapy alone. Therefore, the platinum(II)-loaded gold nanoshells that we proposed herein may be a potential alternative for efficient curative therapy for colorectal cancer. Copyright ? 2020 American Chemical Society.
Subjects
chemotherapy; colorectal cancer; combined therapy; gold nanoshells; photothermal therapy; platinum
SDGs
Other Subjects
Chemotherapy; Diseases; Drug delivery; Infrared devices; Nanostructured materials; Platinum; Platinum compounds; Tumors; Chemotherapeutic drugs; Colorectal cancer; Combined therapy; Gold nano-shells; Inhibition of tumor growth; Photo-thermal conversions; Photothermal therapy; Platinum-based chemotherapy; Nanoshells; antineoplastic agent; gold; metal nanoparticle; platinum complex; animal; Bagg albino mouse; chemistry; colorectal tumor; drug screening; HCT 116 cell line; HT-29 cell line; human; male; metabolism; mouse; nude mouse; pathology; phototherapy; thermotherapy; Animals; Antineoplastic Agents; Colorectal Neoplasms; Gold; HCT116 Cells; HT29 Cells; Humans; Hyperthermia, Induced; Male; Metal Nanoparticles; Mice; Mice, Inbred BALB C; Mice, Nude; Organoplatinum Compounds; Phototherapy; Xenograft Model Antitumor Assays
Publisher
American Chemical Society
Type
journal article