大腸直腸癌腺腫－腺癌自然病史之探討
Other Title
The natural history of adenoma – carcinoma of colorectal cancer
Date Issued
1999
Date
1999
Author(s)
翁昭旼
DOI
882314B002196
Abstract
A matched case-control study in
conjunction with stochastic models is performed. 1.to examine whether diagnosis distribution
of adenoma age diagnosis for is ahead of colorectal cancer. 2.to estimate transition rates from normal, adenoma to colorectal cancer. 3.to calculate 5- and 10-year cumulative
incidence rate of malignant transformation. Our results find that mean (S.D) age of
normal, adenoma and colorectal cancer were
51.71 (16.64) years, 58.55 (13.67) years and
64.09 (12.16) years, respectively. Annual
incidence rate and annual rate of malignamt
transformation aree estimated as 1.21% (95%
CI: 1.17~1.24) and 0.64%(95% CI: 0.57%~
0.72%), respectively. The estimation of
annual incidence of adenoma and annual rate
of malignant transformation stratified by age
show a U-shape figure. The cumulative risk
of malignant transformation from adenoma
to invasive adenocarcinoma by annual, five-yearly
and ten-yearly are 0.48%, 2.37% and
6.95% respectively.
The results imply that ten-yearly
colonscopy screening for adenoma can reduce
approximately 85% invasive adenocarcinoma.
Subjects
Colorectal cancer
Adenoma
Polyp
Nature history
SDGs
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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