Structural studies of the K+ Channel Blocker Tc32,from the Scorpion Tityus cambridgei
Date Issued
2004
Date
2004
Author(s)
Huang, I-Che
DOI
zh-TW
Abstract
Abstracts:
Ion channels are involved in diverse biological processes and play essential roles in the physiology of all cells. An increasing number of human and animal diseases have been identified to relate with the defective function of ion channels. Scorpion venoms contain various polypeptides (channel blockers) that particularly affect the permeability of ion channels in cell membranes. Thus, understanding the structural basis of the specificity of scorpion toxins for these receptors could lead to the design of new ligands with controlled activity and potency for clinical applications. Tc32 is a 35 amino acids peptide from the venom of Brazilian scorpion, Tityus cambridgei, which exhibits blocking activity against Kv1.3 and Shaker B potassium channels with different Kd values and is classified as the first member of the new subfamily of
Subjects
蠍毒
核磁共振
NMR
structure
scorpion toxins
SDGs
Type
other
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