Feeding Effects of Seaweed Diets on hypoglycemic activities in STZ-induced Diabetic Rats
Date Issued
2005
Date
2005
Author(s)
Lee, Chang-Tin
DOI
zh-TW
Abstract
Seaweeds have been utilized as foods and natural medicines by mankind since thousands of years ago. According to the theories of Chinese Traditional Medicine that seaweeds have health promotions and disease curing effects on human bodies. In order to evaluate these effects and promote the functions to the public, three kinds of seaweeds, Porphyra dentata, Gelidium amansii and Eucheuma serra, were selected to investigate the hypoglycemic and hypolipidemic activities on diabetic rats by the experimental animal model. The results may be applied to develop health food products from seaweeds.
40 male wistar rats at 10 or 11 weeks old were induced to type 2 diabetes mellitus by injecting nicotinamide and streptozotocin intraperitoneally. After 7 days, blood samples were drawn and glucose levels were determined to confirm development of diabetes. The diabetic rats were divided randomly into 9 seaweed treatment groups and 1 control group which consisted of 3 or 4 rats each. The rats in seaweed treatment groups were fed on diets in the form of a 9%, 6% or 3% supplement of each seaweed to rodent diet in weight percentile while feeding with unsupplemented rodent diet served as control group. The feeding regimen was designed for 3 periods and each period lasted 10 days. On the last day of each period, rats were fasted for 18-20 hours and blood samples were drawn from heart puncture after anaesthesia by chloral hydrate. The six serum biochemical values from the blood samples: glucose, total cholesterol, triglyceride, blood urea nitrogen (BUN), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined by the automatic blood analyzer. All of above results were tested statistically with the control group by SAS for the effects on the hypoglycemic and hypolipidemic activities.
The results showed that Eucheuma serra groups lowered blood glucose levels significantly, especially in the group of a 9% supplement comparing with the values before feeding seaweed diets while the Porphyra dentate groups and Gelidium amansii groups did not show such effects. Three kinds of seaweeds didn’t have effects on lowering blood lipid, but Eucheuma serra groups showed a tendency to reduce triglyceride levels comparing with other groups. The levels of BUN, ALT and AST were not affected obviously during three feeding regimens. The liver sections showed no apparent difference between treatment groups and control group. There were also no side effects observed on the functions of kidney and liver when feeding with various algal supplements in this experiment.
Subjects
海藻
糖尿病
健康食品
鏈狀致糖素
Diabetic Rats
D.M.
Health Food
Seaweeds
STZ
SDGs
Type
thesis
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