Response to influenza vaccine in children with leukemia undergoing chemotherapy
Journal
Journal of the Formosan Medical Association
Journal Volume
101
Journal Issue
10
Pages
700-704
Date Issued
2002
Author(s)
Abstract
Background and Purpose: To assess the ability of children with acute lymphoblastic leukemia (ALL) to develop an antibody response after influenza vaccination. Method: A total of 65 children under 15 years old were studied, including 25 children with ALL undergoing chemotheraphy, 30 with asthma in remission who were regularly followed at clinics, and 10 healthy children. The influenza vaccine contained antigens B/Yamanashi/166/98, A/New caledonia/20/99/(H1N1), and A/Panama/2007/99(H3N2). Results: Children with ALL developed significant antibody titers to A/Panama/2007/99 antigen 4 weeks after the second immunization. Seroconversion rates after two doses of vaccine were 57.1 to 84.6% and seroresponse rates were between 24 and 60% in children with ALL. Compared to children with asthma in remission, who were regarded as immunocompetent individuals, the ALL children had less seroconversion and lower seroresponse rates to B/Yamanashi/166.98 and A/ Panama/2007/99(H3N2) antigens were comparable in asthmatic and leukemic children. On the other hand, the antibody response in children with ALL who received reinduction chemotherapy suggest that the therapy did not impair seroresponse rates. Conclusion: Our data suggest that the influenza vaccine is safe and effective in children with either ALL or asthma in Taiwan.
SDGs
Other Subjects
influenza vaccine; Influenza virus hemagglutinin; mercaptopurine; methotrexate; prednisolone; vincristine; virus antibody; acute lymphoblastic leukemia; adolescent; anorexia; antibody response; antibody titer; article; asthma; child; clinical trial; controlled clinical trial; controlled study; drug efficacy; drug safety; female; fever; follow up; headache; human; immunization; immunocompetence; influenza; influenza vaccination; Influenza virus A; Influenza virus B; irritability; major clinical study; malaise; male; neurologic disease; pain; randomized controlled trial; remission; seroconversion; treatment outcome; vertigo; virus strain; Antibodies, Viral; Asthma; Child; Female; Humans; Influenza A virus; Influenza Vaccines; Influenza, Human; Leukemia, Lymphocytic, Acute; Male
Type
journal article