Oxidative stress associated with indoor air pollution and sick building syndrome-related symptoms among office workers in Taiwan
Resource
Inhalation Toxicology 19 (1): 57-65
Journal
Inhalation Toxicology
Pages
57-65
Date Issued
2007
Date
2007
Author(s)
Lu, CY
Ma, YC
Lin, JM
Li, CY
Lin, RS
Sung, FC
Abstract
This study investigated whether sick building syndrome (SBS) complaints and indoor air pollution for office workers are associated with oxidative stress indicated by urinary 8-hydroxydeoxyguanosine (8-OHdG). With informed consent, 389 employees in 87 government offices of 8 high-rise buildings in Taipei city completed self-reported questionnaires on SBS complaints at work in the past month. Urinary 8-OHdG was determined for each study participant and on-site air pollutants were measured for each office in both indoor and outdoor air. The results showed that urinary 8-OHdG had significant associations with volatile organic compounds and carbon dioxide levels in offices, and with urinary cotinine levels. The mean urinary 8-OHdG level was also significantly higher in participants with SBS symptoms than in those without such complaints (6.16 vs. 5.45 μg/g creatinine, p = .047). The mean 8-OHdG increased as the number of SBS symptoms increased. The multivariate logistic regression analyses showed that the adjusted odds ratios (OR) in relation to micrograms per gram creatinine increase in 8-OHdG were statistically significant for eye dryness (1.12), upper respiratory syndrome (1.17) with particularly nose itching (1.25), sneezing (1.51), dry throat (1.21), skin dryness (1.31), and dizziness (1.19). This study indicates that the 8-OHdG level was significantly associated with SBS complaints after controlling for air pollution and smoking. Whether the 8-OHdG can be used as an effective predictor for SBS symptoms deserves further study. Copyright © Informa Healthcare.
Other Subjects
8 hydroxydeoxyguanosine; cotinine; creatine; reactive oxygen metabolite; volatile organic compound; adult; air pollutant; air pollution; air quality; allergic rhinitis; allergy; article; cigarette smoking; female; human; indoor air pollution; major clinical study; male; office worker; oxidative stress; priority journal; questionnaire; self report; sick building syndrome; sinusitis; symptomatology; Taiwan; urine level; Adult; Air Pollutants, Occupational; Air Pollution, Indoor; Biological Markers; Carbon Dioxide; Cotinine; Creatinine; Deoxyguanosine; Female; Humans; Logistic Models; Male; Odds Ratio; Organic Chemicals; Oxidative Stress; Questionnaires; Risk Factors; Sampling Studies; Sick Building Syndrome; Smoking; Taiwan; Volatilization
Type
journal article
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