Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians
Journal
Nature genetics
Journal Volume
44
Journal Issue
1
Pages
67
Date Issued
2012
Author(s)
Cho, Yoon Shin
Chen, Chien-Hsiun
Hu, Cheng
Long, Jirong
Ong, Rick Twee Hee
Sim, Xueling
Takeuchi, Fumihiko
Wu, Ying
Go, Min Jin
Yamauchi, Toshimasa
Kwak, Soo Heon
Ma, Ronald C W
Yamamoto, Ken
Adair, Linda S
Aung, Tin
Cai, Qiuyin
Chang, Li-Ching
Chen, Yuan-Tsong
Gao, Yutang
Hu, Frank B
Kim, Hyung-Lae
Kim, Sangsoo
Kim, Young Jin
Lee, Jeannette Jen-Mai
Lee, Nanette R
Li, Yun
Liu, Jian Jun
Lu, Wei
Nakamura, Jiro
Nakashima, Eitaro
Ng, Daniel Peng-Keat
Tay, Wan Ting
Tsai, Fuu-Jen
Wong, Tien Yin
Yokota, Mitsuhiro
Zheng, Wei
Zhang, Rong
Wang, Congrong
So, Wing Yee
Ohnaka, Keizo
Ikegami, Hiroshi
Hara, Kazuo
Cho, Young Min
Cho, Nam H
Bao, Yuqian
Hedman, Åsa K
Morris, Andrew P
McCarthy, Mark I
Takayanagi, Ryoichi
Park, Kyong Soo
Jia, Weiping
Chan, Juliana C N
Maeda, Shiro
Kadowaki, Takashi
Lee, Jong-Young
Wu, Jer-Yuarn
Teo, Yik Ying
Tai, E Shyong
Shu, Xiao Ou
Mohlke, Karen L
Kato, Norihiro
Han, Bok-Ghee
Seielstad, Mark
Abstract
We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-wide association studies (6,952 cases with T2D and 11,865 controls) with a stage 2 in silico replication analysis (5,843 cases and 4,574 controls) and a stage 3 de novo replication analysis (12,284 cases and 13,172 controls). The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3. GLIS3, which is involved in pancreatic beta cell development and insulin gene expression, is known for its association with fasting glucose levels. The evidence of an association with T2D for PEPD and HNF4A has been shown in previous studies. KCNK16 may regulate glucose-dependent insulin secretion in the pancreas. These findings, derived from an east Asian population, provide new perspectives on the etiology of T2D.
Subjects
SUSCEPTIBILITY LOCI; JAPANESE POPULATION; GENETIC-LOCI; VARIANTS; RISK; CHILDHOOD; MELLITUS; COMPLEX; KCNQ1
SDGs
Publisher
NATURE PUBLISHING GROUP
Type
journal article