Application of core-shell electrospinning on wound dressing
Date Issued
2011
Date
2011
Author(s)
Chu, Po-Ying
Abstract
Due to the advance in biomaterial, wound dressing has been fabricated in many forms in recent days, where electrospinning-based material has been known as one of the potential candidates. Since electrospinning consists of advantages due to its high porosity, high specific area, and small pore size, it can mimic the extracellular matrix (ECM) to apply in wound dressing. In this study, core-shell technique was used to fabricate core-shell PLGA-gelatin and gelatin-gelatin fiber meshes to serve as the biomaterial of wound dressing.
Since gelatin consists of high water-solubility, crosslinkage is applied on the fabricated fibers to examine its physical character. Generally, ideal wound dressing should possess great water adsorption; therefore the water capacity of the crosslinked and non-crosslinked fibers was studied. The weight of non-crosslinked fiber meshes were observed to be more than those of crosslinked fiber meshes. However, the water adsorption of non-crosslinked core-shell PLGA-gelatin fiber mesh is shown to be higher than the crosslinked fibers, with even higher degree of water adsorption for fibers that were crosslinked by EDC/NHS. When analyzing the release profile of the fibers, about 80% of the entrapped drugs were released from non-crosslinked core-shell PLGA-gelatin fibers which are twice more than the glutaraldehyde vapor-crosslinked fibers. However, the release from core-shell gelatin-gelatin fiber crosslinked by glutaraldehdye vapor is slower than those of monoaxial gelatin in initial period.
In this study, core-shell electrospinning crosslinked by glutaraldehyde vapor was observed to effectively reduce the weight loss in water with great water adsorption to perform sustained release of drugs.
Subjects
wound dressing
core-shell electrospinning
PLGA
gelatin
drug release
Type
thesis
File(s)![Thumbnail Image]()
Loading...
Name
ntu-100-R98524086-1.pdf
Size
23.54 KB
Format
Adobe PDF
Checksum
(MD5):f0c7c4d5997dde6911cd67ebd52f4da9