Synergistic combinations of tanshinone IIA and trans-resveratrol toward cisplatin-comparable cytotoxicity in HepG2 human hepatocellular carcinoma cells
Journal
Anticancer research
Journal Volume
34
Journal Issue
10
Pages
5473-5480
Date Issued
2014-10
Author(s)
Abstract
To determine the combinative effects of tanshinone IIA (Tan IIA) and trans-resveratrol (Resv) on cytotoxicity, apoptosis, cell-cycle arrest and DNA fragmentation in HepG2 human liver cancer cells.
Subjects
Tanshinone IIA; apoptosis; cell cycle arrest; cisplatin; synergistic combination; trans-resveratrol; Apoptosis; Cell Cycle Checkpoints; Cell Survival; Cisplatin; DNA Fragmentation; Diterpenes, Abietane; Drug Synergism; Hep G2 Cells; Humans; Inhibitory Concentration 50; Resveratrol; Stilbenes
SDGs
Other Subjects
cisplatin; resveratrol; tanshinone IIA; abietane derivative; cisplatin; resveratrol; stilbene derivative; tanshinone; antineoplastic activity; apoptosis; Article; cell cycle arrest; cell cycle S phase; cell death; cell proliferation; cell survival; controlled study; cytotoxicity; DNA fragmentation; drug potentiation; flow cytometry; G1 phase cell cycle checkpoint; G2 phase cell cycle checkpoint; gel electrophoresis; hepatocellular carcinoma cell line; HepG2 cell line; human; IC50; liver cell carcinoma; WST-1 assay; apoptosis; cell cycle checkpoint; chemistry; DNA fragmentation; drug effects; drug potentiation; HepG2 cell line; toxicity; Apoptosis; Cell Cycle Checkpoints; Cell Survival; Cisplatin; Diterpenes, Abietane; DNA Fragmentation; Drug Synergism; Hep G2 Cells; Humans; Inhibitory Concentration 50; Stilbenes
Type
journal article