Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma
Journal
EBioMedicine
Journal Volume
57
Date Issued
2020-07
Author(s)
Lu, Hsuan-Hsuan
Weng, Rueyhung Roc
Juan, Yi-Hsiu
Chen, Yen-Wei
Hung, Zheng-Ci
Oswita, Giovanni Audrey
Huang, Yi-Jhen
Guu, Shih-Yun
Khoo, Kay-Hooi
Abstract
Aberrant fucosylation plays a critical role in lung cancer progression. Nevertheless, the key fucosyltransferase with prognostic significance in lung cancer patients, the enzyme's intracellular targets, and complex molecular mechanisms underlying lung cancer metastasis remain incompletely understood.
Subjects
Cancer metastasis; Fucosyltransferase; Glycoproteomics; Lung cancer; Terminal fucosylation
SDGs
Other Subjects
afatinib; fucosyltransferase; fucosyltransferase 4; galunisertib; mitogen activated protein kinase 3; nerve cell adhesion molecule; proteome; Rab protein; Smad2 protein; transcription factor Snail; transcriptome; unclassified drug; uvomorulin; vimentin; fucosyltransferase; FUT4 protein, human; glycoprotein; transcriptome; animal experiment; animal model; Article; cell invasion assay; cell migration assay; cell proliferation assay; cohort analysis; controlled study; down regulation; epithelial mesenchymal transition; fluorescence microscopy; fucosylation; gene expression; gene expression profiling; human; human cell; human tissue; immunofluorescence; immunoprecipitation; lung adenocarcinoma; lung nodule; major clinical study; male; matrix-assisted laser desorption-ionization mass spectrometry; metastasis; mouse; mRNA expression level; nonhuman; overall survival; phenotype; priority journal; protein expression; real time polymerase chain reaction; recurrence free survival; RNA interference; RNA sequencing; squamous cell lung carcinoma; tumor invasion; tumor xenograft; Western blotting; animal; carcinogenesis; cell adhesion; cell motion; gene expression regulation; genetics; lung adenocarcinoma; metastasis; pathology; signal transduction; tumor cell line; xenograft; Adenocarcinoma of Lung; Animals; Carcinogenesis; Cell Adhesion; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Fucosyltransferases; Gene Expression Regulation, Neoplastic; Glycoproteins; Heterografts; Humans; Mice; Neoplasm Metastasis; Signal Transduction; Transcriptome
Type
journal article