Factors associated with isolated anti-hepatitis B core antibody in HIV-positive patients: Impact of compromised immunity
Journal
Journal of Viral Hepatitis
Journal Volume
17
Journal Issue
8
Pages
578-587
Date Issued
2010
Author(s)
Lee H.-C.
Liu C.-E.
Yang C.-L.
Su S.-C.
Ko W.-C.
Lin C.-Y.
Tsai J.-J.
Wong W.-W.
Ho M.-W.
Cheng S.-H.
Lin Y.-H.
Miao W.-J.
Abstract
In regions that are hyperendemic for chronic hepatitis B virus (HBV) infection, prevalence of and risk factors associated with isolated anti-hepatitis B core antibody (anti-HBc) in HIV-positive patients are less well described. HIV-positive patients who were tested for hepatitis B surface antigen (HBsAg), anti-hepatitis B surface antibody (anti-HBs) and anti-HBc at designated hospitals for HIV care in Taiwan were included for analysis. HBV DNA was detected by real-time polymerase chain reaction in patients with and without isolated anti-HBc. Of 2351 HIV-positive patients, 450 (19.1%) were HBsAg positive, 411 (17.5%) were anti-HBc positive alone and 963 (41.0%) for both anti-HBs and anti-HBc. Compared with patients who were positive for both anti-HBs and anti-HBc, patients with isolated anti-HBc were older, less likely to have anti-hepatitis C virus antibody (anti-HCV), had lower CD4 lymphocyte counts and higher plasma HIV RNA loads. Older age (adjusted odds ratio, 1.029; 95% confidence interval, 1.015-1.043) and CD4 <100 cells/μL (adjusted odds ratio, 1.524; 95% confidence interval, 1.025-2.265) were independently associated with isolated anti-HBc by logistic regression, while presence of anti-HCV and injecting drug use were not. HBV DNA was detectable in 8.3% of 277 patients with isolated anti-HBc and 14.3% of 56 patients with both anti-HBs and anti-HBc (P = 0.160). In a country hyperendemic for HBV infection, HIV-positive patients at older age and with CD4 <100 cells/μL were more likely to have isolated anti-HBc, suggesting that compromised immunity plays a role in the presence of this marker. ? 2009 Blackwell Publishing Ltd.
SDGs
Other Subjects
hepatitis B core antibody; hepatitis B surface antibody; hepatitis B surface antigen; lamivudine; virus DNA; virus RNA; hepatitis B antibody; adolescent; adult; antibody isolation; article; CD4 lymphocyte count; controlled study; female; hepatitis B; hepatitis C; human; Human immunodeficiency virus infection; immunocompromised patient; major clinical study; male; Mirabilis; prevalence; priority journal; real time polymerase chain reaction; risk factor; virus load; blood; complication; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Human immunodeficiency virus; immunology; middle aged; retrospective study; statistical model; Taiwan; virology; young adult; Adolescent; Adult; Hepatitis B Antibodies; Hepatitis B virus; Hepatitis B, Chronic; HIV; HIV Infections; Humans; Logistic Models; Middle Aged; Retrospective Studies; Seroepidemiologic Studies; Taiwan; Young Adult
Publisher
Blackwell Publishing Ltd
Type
journal article