Inhibition of Escherichia coli-Induced Meningitis by Carboxyfullerence
Resource
Antimicrobial Agents and Chemotherapy 43 (9): 2273-2277
Journal
Antimicrobial Agents and Chemotherapy
Journal Volume
43
Journal Issue
9
Pages
2273-2277
Date Issued
1999
Date
1999
Author(s)
Abstract
The effect of a water-soluble malonic acid derivative of carboxyfullerence (C60) against Escherichia coli-induced meningitis was tested. C60 can protect the mice from E. coli-induced death in a dose-dependent manner. C60 administered intraperitoneally as late as 9 h after E. coli injection was still protective. The C60-treated mice had less tumor necrosis factor alpha and interleukin-1beta production by staining of brain tissue compared to the levels of production for nontreated mice. The E. coli-induced increases in blood-brain barrier permeability and inflammatory neutrophilic infiltration were also inhibited. These data suggest that C60 is a potentially therapeutic agent for bacterial meningitis.
SDGs
Type
journal article
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