Invasive Pathobionts Contribute to Colon Cancer Initiation by Counterbalancing Epithelial Antimicrobial Responses
Journal
Cellular and molecular gastroenterology and hepatology
Journal Volume
13
Journal Issue
1
Pages
57
Date Issued
2022-01
Author(s)
Li, Yi-Hsuan
Lin, Po-Yu
Chang, Xin-Yu
Weng, Jui-Ping
Shue, Yin-Wen
Abstract
Microbiota dysbiosis and mucosa-associated bacteria are involved in colorectal cancer progression. We hypothesize that an interaction between virulent pathobionts and epithelial defense promotes tumorigenesis.
Subjects
Colon Carcinoma; Gut Microbiome; Intestinal Epithelial Cells; Intracellular Microbes; Organoids and Spheroids; Reactive Oxygen Species; Xenophagy
SDGs
Other Subjects
amikacin; ampicillin; antibiotic agent; cefazolin; cefepime; cefmetazole; cefotaxime; ceftazidime; ciprofloxacin; clindamycin; daptomycin; dual oxidase; ertapenem; erythromycin; free radical; gentamicin; imipenem; levofloxacin; linezolid; meropenem; micro
Type
journal article