Diphosphate formation using cyanuric chloride or triisopropylbenzenesulfonyl chloride as the activating agents
Journal
Tetrahedron Letters
Journal Volume
52
Journal Issue
17
Pages
2232-2234
Date Issued
2011
Author(s)
Lin, Teng-Chi
Abstract
By using cyanuric chloride or 2,4,6-triisopropylbenzenesulfonyl chloride (TIPSCl) as the condensing agent and magnesium bromide as the promoter, the phosphate cross-coupling reactions are effectively carried out to give lipid-saccharide and pyrrolidine-guanosine diphosphates. Under optimized conditions, the TIPSCl-facilitated cross-coupling reactions complete in a short reaction time (∼5 h) without the complication of possible self-coupling reactions. © 2011 Elsevier Ltd. All rights reserved.
By using cyanuric chloride or 2,4,6-triisopropylbenzenesulfonyl chloride (TIPSCl) as the condensing agent and magnesium bromide as the promoter, the phosphate cross-coupling reactions are effectively carried out to give lipid-saccharide and pyrrolidine-guanosine diphosphates. Under optimized conditions, the TIPSCl-facilitated cross-coupling reactions complete in a short reaction time (∼5 h) without the complication of possible self-coupling reactions. © 2011 Elsevier Ltd. All rights reserved.
SDGs
Type
journal article