急性骨髓性白血病SOCS-1基因及SHP-1基因異常甲基化之研究(1/2)
Other Title
SOCS1 Methylation in Patients With Newly
Diagnosed Acute Myeloid Leukemia
Diagnosed Acute Myeloid Leukemia
Date Issued
2004
Date
2004
Author(s)
田蕙芬
DOI
922314B002169
Abstract
The proliferation and differentiation of hematopoietic precursor cells depend on various cytokines.The suppressor of
cytokine signaling-1 (SOCS1 )down-regulates Janus kinases/signal transducers and activators of transcription (JAK/STAT )
pathway activity and inhibits the biological effects of cytokines.SOCS1 has been shown to have tumor-suppressor activity,and
methylation of this gene,resulting in transcriptional silencing,has been found in 65%of hepatocellular carcinoma and has been
suggested to play an important role in the development of the cancer.The methylation status of the SOCS1 gene in acute
myeloid leukemia (AML)has not been reported before.In this study,we analyzed SOCS1 methylation in 89 patients with newly
diagnosed AML and correlated the result with immunophenotypes,cytogenetics,clinical features,and treatment outcome.
SOCS1 methylation was found in the leukemic cells from 53 patients (60%).Thirteen (76%)of the 17 patients with t(15;17)
had SOCS1 methylation,whereas this gene was methylated in only one (11%)of the nine patients with t(8;21).The frequencies
of SOCS1 methylation among various cytogenetic subgroups differed signi ficantly (P 0.014).Other clinical and laboratory
parameters and the disease-free survival and overall survival were similar between patients with and without SOCS1
methylation.In conclusion,SOCS1 methylation occurs in more than half of AML cases,correlates with cytogenetic abnor-
malities,and may play an important role in the development of subsets of AML.
SDGs
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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